Detection of oncogenic mutations
Histone mutations are associated with some types of cancer, such as gliomas and osteosarcomas. These mutations generally exist in the N-terminal tail or globular domains of histone proteins and some act in a dominant fashion.
Certain mutations occur at or nearby post-translationally-modified sites (PTMs), and thus could disrupt the reading, writing and erasing of certain epigenetic marks.
EpiQMAx analysis workflows can test for the presence of these mutations in biological samples and can asses the effect that they have on the abundance of histone PTMs.
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